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10.1016/j.jtos.2025.02.010 25 LiuJ.XiaoC.WangH.XueY.DongD.LinC.et al (2017)
But in patients with pre-existing inflammatory bowel disease, the inflammatory cascade in the colon may be sensitized or amplified by GLP-1 activation, potentially triggering flares or worsening existing inflammation
The GH/IGF-1 Axis in Cirrhosis Chronic liver disease already disrupts GH signaling
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Participants on the same dosing level for longer periods generally showed more sustained improvements, reinforcing that retatrutide works cumulatively over time
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